After an astronaut becomes host to an extraterrestrial virus in space and is transported back to earth in a vegetative state, the most advanced medical minds in the United States are perplexed as their patient undergoes a dramatic transformation.

When the patient awakens and begins to savagely attack everyone in the hospital, the rapid spread of the virus commences.

Only five years later, humans are almost nothing more than a distant memory. Instead the virus has transformed them into creepersmindless predators that savagely hunt and kill.

Drake and Jason Bennett are two of the last humans on Earth. The brothers fight for survival every day in their hometown of New York City, but creepers seem to lurk in every alley and hunt through the city streets by both day and night.

When news of a potential survivor colony reaches the Bennett brothers, they decide to travel across the decimated United States.

Join Jason and Drake as they face countless challenges that push them to the brink of sanity in their daily struggles while searching for the remnants of humanity and a way to beat the virus.